Test–retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteers

  title={Test–retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteers},
  author={Sara De Simoni and Adam J. Schwarz and Owen G. O'Daly and Andre F. Marquand and Claire Brittain and C. Gonzales and S. Stephenson and Stephen C. R. Williams and Mitul A. Mehta},
The pharmacological MRI (phMRI) technique is being increasingly used in both pre-clinical and clinical models to investigate pharmacological effects on task-free brain function. Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, induces a strong phMRI response and represents a promising pharmacological model to investigate the role of glutamatergic abnormalities in psychiatric symptomatology. The aim of this study was to assess whether the brain response to ketamine is reliable in… CONTINUE READING
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