Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats.

Abstract

UNLABELLED Increased production of vasoconstrictive prostanoids, such as thromboxane A2 (TXA2 ), contributes to endothelial dysfunction and increased hepatic vascular tone in cirrhosis. TXA2 induces vasoconstriction by way of activation of the thromboxane-A2 /prostaglandin-endoperoxide (TP) receptor. This study investigated whether terutroban, a specific TP… (More)
DOI: 10.1002/hep.26520

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@article{Rosado2013TerutrobanAT, title={Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats.}, author={Eugenio Rosado and Aina Rodr{\'i}guez-Vilarrupla and Jorge Gracia-Sancho and Dinesh M Tripathi and H{\'e}ctor Garc{\'i}a-Calder{\'o} and Jaume Martin Bosch and Juan Carlos Garc{\'i}a-Pag{\'a}n}, journal={Hepatology}, year={2013}, volume={58 4}, pages={1424-35} }