Tertiary structure prediction and identification of druggable pocket in the cancer biomarker – Osteopontin-c

@inproceedings{Sivakumar2014TertiarySP,
  title={Tertiary structure prediction and identification of druggable pocket in the cancer biomarker – Osteopontin-c},
  author={Subramaniam Sivakumar and Sivasitambaram Niranjali Devaraj},
  booktitle={Journal of diabetes and metabolic disorders},
  year={2014}
}
BACKGROUND Osteopontin (Eta, secreted sialoprotein 1, opn) is secreted from different cell types including cancer cells. Three splice variant forms namely osteopontin-a, osteopontin-b and osteopontin-c have been identified. The main astonishing feature is that osteopontin-c is found to be elevated in almost all types of cancer cells. This was the vital point to consider it for sequence analysis and structure predictions which provide ample chances for prognostic, therapeutic and preventive… CONTINUE READING

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