Tertiary network in mammalian mitochondrial tRNAAsp revealed by solution probing and phylogeny

@article{Messmer2009TertiaryNI,
  title={Tertiary network in mammalian mitochondrial tRNAAsp revealed by solution probing and phylogeny},
  author={M. Messmer and J. P{\"u}tz and T. Suzuki and Tsutomu Suzuki and C. Sauter and M. Sissler and Florentz Catherine},
  journal={Nucleic Acids Research},
  year={2009},
  volume={37},
  pages={6881 - 6895}
}
Primary and secondary structures of mammalian mitochondrial (mt) tRNAs are divergent from canonical tRNA structures due to highly skewed nucleotide content and large size variability of D- and T-loops. The nonconservation of nucleotides involved in the expected network of tertiary interactions calls into question the rules governing a functional L-shaped three-dimensional (3D) structure. Here, we report the solution structure of human mt-tRNAAsp in its native post-transcriptionally modified… Expand
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