Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response

@article{Kuerten2012TertiaryLO,
  title={Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response},
  author={Stefanie Kuerten and Achim Schickel and Christian Kerkloh and Mascha S. Recks and Klaus Addicks and Nancy H. Ruddle and Paul Viktor Lehmann},
  journal={Acta Neuropathologica},
  year={2012},
  volume={124},
  pages={861-873}
}
While the role of T cells has been studied extensively in multiple sclerosis (MS), the pathogenic contribution of B cells has only recently attracted major attention, when it was shown that B cell aggregates can develop in the meninges of a subset of MS patients and were suggested to be correlates of late-stage and more aggressive disease in this patient population. However, whether these aggregates actually exist has subsequently been questioned and their functional significance has remained… CONTINUE READING
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