Tertiary N-glucuronides of clozapine and its metabolite desmethylclozapine in patient urine.

@article{BreyerPfaff2001TertiaryNO,
  title={Tertiary N-glucuronides of clozapine and its metabolite desmethylclozapine in patient urine.},
  author={Ursula Breyer-Pfaff and Henning Wachsmuth},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2001},
  volume={29 10},
  pages={1343-8}
}
In experiments with expressed human UDP-glucuronosyltransferase 1A4 (UGT1A4), the antipsychotic clozapine proved to be conjugated to two different glucuronides, one of which was identified as the quaternary ammonium glucuronide derivatized at the N-methylpiperazine group; this compound had previously been isolated from patient urine. An additional glucuronide produced in larger quantity was assumed to be conjugated at the secondary nitrogen of the central ring to form 5-N-glucuronide, but this… CONTINUE READING
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Clearance-Messungen für Clozapin und seine Metabolite N-Desmethylclozapin und Clozapin-N-oxid bei schizophrenen Patienten und Isolierung und Strukturaufklärung weiterer Metabolite aus Patientenurin

  • G Schaber
  • Ph.D. thesis,
  • 1998
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