Tertiary Lymphoid Structures in Rheumatoid Arthritis: NF-κB-Inducing Kinase-Positive Endothelial Cells as Central Players.

@article{Noort2015TertiaryLS,
  title={Tertiary Lymphoid Structures in Rheumatoid Arthritis: NF-κB-Inducing Kinase-Positive Endothelial Cells as Central Players.},
  author={Ae Ri Noort and Katinka P M van Zoest and Lisa G. M. van Baarsen and Chrissta X. Maracle and Boy Helder and Natalie Papazian and Monica Romera-Hernandez and Paul Peter Tak and Tom Cupedo and Sander W. Tas},
  journal={The American journal of pathology},
  year={2015},
  volume={185 7},
  pages={
          1935-43
        }
}
Tertiary lymphoid structures (TLSs) in chronic inflammation, including rheumatoid arthritis (RA) synovial tissue (ST), often contain high endothelial venules and follicular dendritic cells (FDCs). Endothelial cell (EC)-specific lymphotoxin β (LTβ) receptor signaling is critical for the formation of lymph nodes and high endothelial venules. FDCs arise from perivascular platelet-derived growth factor receptor β(+) precursor cells (preFDCs) that require specific group 3 innate lymphoid cells… CONTINUE READING
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