Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1β, IL-6 and IL-10 on human macrophages

@article{Nogueira2014Terpinen4olAA,
  title={Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1β, IL-6 and IL-10 on human macrophages},
  author={Marianne Nicole Marques Nogueira and Sabrina Garcia de Aquino and Carlos R. Bueno J{\'u}nior and Denise Madalena Palomari Spolidorio},
  journal={Inflammation Research},
  year={2014},
  volume={63},
  pages={769-778}
}
Tea tree oil (TTO) is an essential oil with anti-inflammatory properties, steam distilled from the plant Melaleuca alternifolia. We investigated the immunomodulatory properties of TTO and its components (terpinen-4-ol and alpha-terpineol) using lipopolysaccharide (LPS)-stimulated macrophages. The ability of TTO, terpinen-4-ol and alpha-terpineol to modulate the macrophage response to bacterial LPS stimulation was assessed by ELISA for tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and… CONTINUE READING
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