Terpenoids of Sinularia.: Chemistry and Biomedical Applications

  title={Terpenoids of Sinularia.: Chemistry and Biomedical Applications},
  author={Haidy Nasr Kamel and Marc Slattery},
  journal={Pharmaceutical Biology},
  pages={253 - 269}
Abstract The soft coral genus Sinularia. is one of the most widely distributed soft corals. It constitutes a dominant portion of the biomass in the tropical reef environment. Sinularia. elaborates a rich harvest of secondary metabolites including sesquiterpenes, diterpenes, polyhydroxylated steroids, and polyamine compounds. These metabolites were recently shown to possess a range of biological activities such as antimicrobial, anti-inflammatory, and cytotoxic activities. During the past decade… 
Casbane Diterpenes from Red Sea Coral Sinularia polydactyla.
A solvent extract of Sinularia polydactyla resulted in the isolation of three new casbane diterpenes, which were elucidated on the basis of spectroscopic analyses and confirmed by X-ray analysis.
Hurgadacin: A new steroid from Sinularia polydactyla
Bioactive Cembrane Derivatives from the Indian Ocean Soft Coral, Sinularia kavarattiensis
Examination of marine-derived substances for their bioactive properties in a cell-based Chikungunya virus (CHIKV) replicon model and for in vitro anti-inflammatory activity found compound 2 was shown to modulate the immune response in microglial cells and to possess potential anti- inflammation properties by dose-dependently reducing the release of pro- and anti- inflammatory cytokines.
Sesquiterpene constituents from the soft coral Sinularia nanolobata
Using various chromatographic separations, four sesquiterpenes, including two new compounds, Nanolobatols A and B, were isolated from the Vietnamese soft coral Sinularia nanolobata, and their structures were determined on the basis of spectroscopic data and by comparison with the literature values.
Terpenoids from the South China Sea soft coral Sinularia multiflora
Abstract A rare sinulariane-type norcembranoid sinulariadiolide B (1) with a unique cyano group, and a eunicellin-based diterpenoid multifloralin (2), along with two known related analogues,
Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata
Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral
Further casbane-type diterpenes from the soft coral Sinularia depressa.
Eudesmane and aromadendrane sesquiterpenoids from the Vietnamese soft coral Sinularia erecta
Abstract Using various chromatographic separations, eight sesquiterpenoids (1–8), including one new compound 3β,5α-dihydroxyeudesma-4(15),11-diene (1), were isolated from the MeOH extract of the


Marine Terpenes and Terpenoids. III. Isolation and Structures of Two Cembrane Diols from the Soft Coral Sinularia mayi
Nine cembrane-type diterpenes were isolated from the lipid extract of the soft coral, Sinularia mayi. Of these, seven α-methylene-γ-lactone derivatives (1-7) had been previously isolated from various
New Sesquiterpenoid from the Soft Coral Sinularia dissecta
In continuation of our interest in the bioactive secondary metabolites from the marine organisms, we examined the soft coral Sinularia dissecta Tixier Durivault (Afcyoniidae) collected from the
Drugs from the seas – current status and microbiological implications
Molecular methods have successfully been applied to study the microbial diversity in marine sponges and to gain evidence for an involvement of bacteria in the biosynthesis of the bryostatins in the Bryozoan Bugula neritina.
Sinulariadiolide, a Novel Marine Norditerpenoid from Okinawan Soft Coral of the Genus, Sinularia
A new marine norditerpenoid, sinulariadiolide, was isolated from Okinawan soft coral of the genus, Sinularia. Its structure was determined by spectroscopic analysis and chemical reaction. This
Several new isoprenoids from the soft coral sinularia erecta
Eight compounds were isolated from the Indo-Pacific soft coral Sinularia erecta collected from the lagoon of Mayotte, Comoros Islands, northwest of Madagascar by means of 1D and 2D NMR and MS spectroscopy in addition to some chemical transformations.
Marine terpenes and terpenoids. VI: Isolation of several plausible precursors of marine cembranolides, from the soft coral, Sinularia mayi
Six new cembranoid diterpenes, sinulariols C and D (1 and 2a), sinularial A (3), sinularic acid A (4), and sinularones A and B (5 and 6) were isolated from the lipid extract of the soft coral
Marine Terpenes and Terpenoids. IV. Isolation of New Cembranoid and Secocembranoid Lactones from the Soft Coral Sinularia mayi
Four α-methylene-γ-lactone derivatives, designated as mayolide A to mayolide D, were isolated from the soft coral Sinularia mayi. From the spectroscopic data and correlations to known compounds, they