• Corpus ID: 4673491

Terpendoles , Novel ACATInhibitors Produced by Albophoma yamanashiensis III . Production , Isolation and Structure Elucidation of NewComponents

@inproceedings{Hiroshi2006TerpendolesN,
  title={Terpendoles , Novel ACATInhibitors Produced by Albophoma yamanashiensis III . Production , Isolation and Structure Elucidation of NewComponents},
  author={Hiroshi and Tomoda and Noriko and Tabata and Da-jun and Yang and Hiroaki and Takayanagi and Satoshi and Omura},
  year={2006}
}
Eight new components of terpendoles E to L were isolated and characterized from the culture broth of Albophomayamanashiensis using a different production medium. All the structures were elucidated by spectroscopic analyses including various NMRexperiments, indicating that all the terpendoles have the same indoloditerpene core as terpendoles A to D. Terpendoles J, K and L showed the moderate inhibition against acyl-CoA : cholesterol acyltransferase (ACAT)activity with IC50 values of 38.8, 38.0… 

References

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Terpendoles , Novel ACATInhibitors Produced by Albophoma yamanashiensis I . Production , Isolation and Biological Properties

A series of new acyl-CoA: cholesterol acyltransferase (ACAT)inhibitors termed terpendoles were isolated from the culture broth of a fungal strain FO-2546 which was proposed to belong to a new genus designated as Albophomayamanashiensis, and exhibited the highest specificity (cytotoxicity vs. ACATinhibition) among microbial ACATInhibitors the authors discovered so far.

Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D.

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