Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components.

@article{Tomoda1995TerpendolesNA,
  title={Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components.},
  author={Hiroshi Tomoda and Noriko Tabata and D. J. Yang and Hiroaki Takayanagi and Satoshi Ōmura},
  journal={The Journal of antibiotics},
  year={1995},
  volume={48 8},
  pages={
          793-804
        }
}
Eight new components of terpendoles E to L were isolated and characterized from the culture broth of Albophoma yamanashiensis using a different production medium. All the structures were elucidated by spectroscopic analyses including various NMR experiments, indicating that all the terpendoles have the same indoloditerpene core as terpendoles A to D. Terpendoles J, K and L showed the moderate inhibition against acyl-CoA: cholesterol acyltransferase (ACAT) activity with IC50 values of 38.8, 38.0… 

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Evaluation of terpendoles from the culture broth of a fungal strain FO-2546 indicated that terpendole D exhibited the highest specificity (cytotoxicity vs. ACAT inhibition) among microbial ACAT inhibitors the authors discovered so far.

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Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies and by NOE experiments and X-ray crystallographic analysis.

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