Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components.

@article{Tomoda1995TerpendolesNA,
  title={Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components.},
  author={Hiroshi Tomoda and Noriko Tabata and Duck Joo Yang and Hisao Takayanagi and Satoshi O̅mura},
  journal={The Journal of antibiotics},
  year={1995},
  volume={48 8},
  pages={
          793-804
        }
}
Eight new components of terpendoles E to L were isolated and characterized from the culture broth of Albophoma yamanashiensis using a different production medium. All the structures were elucidated by spectroscopic analyses including various NMR experiments, indicating that all the terpendoles have the same indoloditerpene core as terpendoles A to D. Terpendoles J, K and L showed the moderate inhibition against acyl-CoA: cholesterol acyltransferase (ACAT) activity with IC50 values of 38.8, 38.0… CONTINUE READING
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