Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D.

@article{Huang1995TerpendolesNA,
  title={Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D.},
  author={X H Huang and Hiroyuki Nishida and Hiroshi Tomoda and Noriko Tabata and Kazuro Shiomi and D. J. Yang and Hiroaki Takayanagi and Satoshi Ōmura},
  journal={The Journal of antibiotics},
  year={1995},
  volume={48 1},
  pages={
          5-11
        }
}
Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies. All terpendoles consist of diterpene and indole moieties in common. Terpendoles A, C and D possess an additional isoprenyl unit via oxygen atom(s) of their diterpene moieties. The relative stereochemistries of terpendoles C and D were confirmed by NOE experiments and X-ray crystallographic analysis. 

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