Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy models.

@article{Motamedi2006TerminationOE,
  title={Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy models.},
  author={Gholam K Motamedi and Patricia Salazar and Eric L. P. Smith and Ronald Peter Lesser and William R. S. Webber and Pavel I Ortinski and Stefano Vicini and Michael A Rogawski},
  journal={Epilepsy research},
  year={2006},
  volume={70 2-3},
  pages={200-10}
}
Cooling has been shown to terminate experimentally induced epileptiform activity in models of epilepsy without causing injury to the cooled brain, suggesting that cooling could represent an approach to seizure control in intractable focal epilepsies. Here we sought to determine the most effective way to apply cooling to abort spontaneous epileptiform discharges in in vitro brain slice models. We induced spontaneous epileptiform activity in rat brain slices by exposure to 4-aminopyridine (4-AP… CONTINUE READING

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