Termination of calcium-induced calcium release by induction decay: an emergent property of stochastic channel gating and molecular scale architecture.

@article{Laver2013TerminationOC,
  title={Termination of calcium-induced calcium release by induction decay: an emergent property of stochastic channel gating and molecular scale architecture.},
  author={Derek R. Laver and Cherrie H. T. Kong and Mohammad Imtiaz and Mark B. Cannell},
  journal={Journal of molecular and cellular cardiology},
  year={2013},
  volume={54},
  pages={98-100}
}
Calcium-induced calcium release (CICR) is an inherently regenerative process due to the Ca(2+)-dependent gating of ryanodine receptors (RyRs) in the sarco/endoplasmic reticulum (SR) and is critical for cardiac excitation-contraction coupling. This process is seen as Ca(2+) sparks, which reflect the concerted gating of groups of RyRs in the dyad, a specialised junctional signalling domain between the SR and surface membrane. However, the mechanism(s) responsible for the termination of… CONTINUE READING

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