Termination of acute-phase response: role of some cytokines and anti-inflammatory drugs.

@article{Koj1998TerminationOA,
  title={Termination of acute-phase response: role of some cytokines and anti-inflammatory drugs.},
  author={Aleksander Koj},
  journal={General pharmacology},
  year={1998},
  volume={31 1},
  pages={9-18}
}
1. The acute-phase response is triggered by changes in intracellular mediators that activate stress-sensitive kinases and transcription factors controlling the synthesis of proinflammatory cytokines such as TNF-alpha, IL-1, IL-8 or IFN-gamma. 2. Natural extinguishing of acute-phase response occurs due to short half-lives of inflammatory mediators and production of anti-inflammatory cytokines such as IL-10, IL-4, IL-13, TGF-beta and some others. 3. Excess proinflammatory cytokines are removed by… CONTINUE READING
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