End of the Beginning: Elongation and Termination Features of Alternative Modes of Chromosomal Replication Initiation in Bacteria
- Jayaraman Gowrishankar
- PLoS genetics
In this issue of Molecular Cell, Fachinetti et al. provide the first comprehensive map of replication termination sites (TERs) in Saccharomyces cerevisiae (Fachinetti et al., 2010). Strikingly, the majority of TERs are occupied by topoisomerase 2, which shields these regions against genomic instability.