Terminal modifications of norovirus P domain resulted in a new type of subviral particles, the small P particles.

@article{Tan2011TerminalMO,
  title={Terminal modifications of norovirus P domain resulted in a new type of subviral particles, the small P particles.},
  author={Ming Tan and Ping-an Fang and Ming Xia and Teepanis Chachiyo and Wen Jiang and Xi Jiang},
  journal={Virology},
  year={2011},
  volume={410 2},
  pages={345-52}
}
The protruding (P) domain of norovirus VP1 is responsible for immune recognition and host receptor interaction. Our previous studies have demonstrated that a modification of the ends of the P domain affects the conformation and/or function of the P protein. An expression of the P domain with or without the hinge, or with an additional cysteine at either ends of the P protein resulted in P dimers and/or P particles. Here we report a new type of subviral particle, the small P particles, through a… CONTINUE READING

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