Terminal deoxynucleotidyl transferase-positive B cell precursors in fetal lymph nodes and extrahemopoietic tissues.

@article{Cattoretti1989TerminalDT,
  title={Terminal deoxynucleotidyl transferase-positive B cell precursors in fetal lymph nodes and extrahemopoietic tissues.},
  author={Giorgio Cattoretti and Carlo Parravicini and Antonio Bonati and Mauro Buscaglia and Giovanni Zuliani and Alessandro Plebani and Domenico Delia and Franco Rilke},
  journal={European journal of immunology},
  year={1989},
  volume={19 3},
  pages={493-500}
}
Terminal deoxynucleotidyl transferase (TdT)-positive B cell precursors populate fetal lymph nodes (LN) of mid-term (16th-22th week) fetuses. These cells have a B cell phenotype (HLA-DR, CD45R, CD22, mu) and lack mature differentiation antigens (CD1c, CD20, L26). TdT+ cells are also present in the extranodal mesenteric mesenchyme, pancreas and LN primordia. Extranodal TdT+ cells are found among proliferating (i.e. Ki-67+) B cells and lack leukocyte function-associated antigen (LFA-1) and HLA-DQ… CONTINUE READING
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