Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase.

@article{Motea2010TerminalDT,
  title={Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase.},
  author={Edward A. Motea and Anthony Berdis},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1804 5},
  pages={
          1151-66
        }
}
Nearly every DNA polymerase characterized to date exclusively catalyzes the incorporation of mononucleotides into a growing primer using a DNA or RNA template as a guide to direct each incorporation event. There is, however, one unique DNA polymerase designated terminal deoxynucleotidyl transferase that performs DNA synthesis using only single-stranded DNA as the nucleic acid substrate. In this chapter, we review the biological role of this enigmatic DNA polymerase and the biochemical mechanism… CONTINUE READING

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