Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells.

  title={Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells.},
  author={Jose A Halperin and Alane Taratuska and Anne Nicholson-Weller},
  journal={The Journal of clinical investigation},
  volume={91 5},
The membrane attack complex of complement (MAC) can induce reversible changes in cell membrane permeability resulting in significant but transient intracellular ionic changes in the absence of cell lysis. Because ion fluxes and cytosolic ionic changes are integral steps in the signaling cascade initiated when growth factors bind to their receptors, we hypothesized that the MAC-induced reversible changes in membrane permeability could stimulate cell proliferation. Using purified terminal… CONTINUE READING


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