Terminal Endbuds and Acini as the Respective Major Targets for Chemical and Sporadic Carcinogenesis in the Mammary Glands of Human c-Ha-ras Protooncogene Transgenic Rats

@article{Hamaguchi2004TerminalEA,
  title={Terminal Endbuds and Acini as the Respective Major Targets for Chemical and Sporadic Carcinogenesis in the Mammary Glands of Human c-Ha-ras Protooncogene Transgenic Rats},
  author={Tetsuya Hamaguchi and Yoichiro Matsuoka and Hiroaki Kawaguchi and Katsumi Fukamachi and Nobuo Takasuka and Shinobu Ueda and Kimiko Shimizu and M. Ohki and Masato Kusunoki and Teruyo Sakakura and Hiroki Yoshida and Hiroyuki Tsuda},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={83},
  pages={43-56}
}
  • Tetsuya Hamaguchi, Yoichiro Matsuoka, +9 authors Hiroyuki Tsuda
  • Published in
    Breast Cancer Research and…
    2004
  • Biology, Medicine
  • A rat strain carrying the human c-Ha-ras protooncogene, established by our laboratory, is highly susceptible to mammary chemical carcinogens. The transgenic rats exhibit increased number of terminal endbuds (TEBs) at the tips of developing ducts in the mammary gland compared to non-transgenic littermates. Confocal microscopy revealed the level of active mitogen-activated protein kinase to be elevated in these TEBs, and a close correlation between their numbers and tumorigenic response initiated… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 47 REFERENCES

    Biological and molecular bases of mammary carcinogenesis.

    VIEW 9 EXCERPTS
    HIGHLY INFLUENTIAL

    Experimentally induced mammary tumors in rats

    VIEW 1 EXCERPT

    Cyclins and breast cancer

    VIEW 1 EXCERPT

    Ras activation in human breast cancer

    VIEW 1 EXCERPT

    Biological and molecular characteristics of the premalignant mouse mammary gland

    • D Medina
    • Biochim Biophys Acta 1603:
    • 2002
    VIEW 2 EXCERPTS

    Genetic and epigenetic alterations in colon cancer.

    VIEW 2 EXCERPTS