Term human fetal membranes have a weak zone overlying the lower uterine pole and cervix before onset of labor.

@article{Khwad2005TermHF,
  title={Term human fetal membranes have a weak zone overlying the lower uterine pole and cervix before onset of labor.},
  author={Mohammed El Khwad and Bradley P Stetzer and Robert Michael Moore and Deepak Kumar and Bobby Mercer and Sunny Arikat and Raymond W Redline and Joseph M. Mansour and John Jamison . Moore},
  journal={Biology of reproduction},
  year={2005},
  volume={72 3},
  pages={
          720-6
        }
}
The etiology of fetal membrane (FM) rupture is unknown. A hypothesis that the FM weakens by a process of collagen remodeling and apoptosis to facilitate rupture has been proposed. Human FMs reportedly exhibit a zone of altered histology, postulated to be the FM rupture site, but concomitant FM weakness has not been demonstrated. We hypothesized that a discrete zone of FM with marked weakness, histological change, and evidence of remodeling and apoptosis, develops in late gestation in the FM… CONTINUE READING

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