Terbium-mediated footprinting probes a catalytic conformational switch in the antigenomic hepatitis delta virus ribozyme.

Abstract

The two forms of the hepatitis delta virus ribozyme are derived from the genomic and antigenomic RNA strands of the human hepatitis delta virus (HDV), where they serve a crucial role in pathogen replication by catalyzing site-specific self-cleavage reactions. The HDV ribozyme requires divalent metal ions for formation of its tertiary structure, consisting… (More)

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@article{Harris2004TerbiummediatedFP, title={Terbium-mediated footprinting probes a catalytic conformational switch in the antigenomic hepatitis delta virus ribozyme.}, author={Dinari A. Harris and Rebecca A Tinsley and Nils G. Walter}, journal={Journal of molecular biology}, year={2004}, volume={341 2}, pages={389-403} }