Terbinafine: Mode of action and properties of the squalene epoxidase inhibition

@article{Ryder1992TerbinafineMO,
  title={Terbinafine: Mode of action and properties of the squalene epoxidase inhibition},
  author={Neil S. Ryder},
  journal={British Journal of Dermatology},
  year={1992},
  volume={126}
}
  • N. Ryder
  • Published 1 February 1992
  • Biology
  • British Journal of Dermatology
Terbinafine (Lamisil®) has primary fungicidal action against many fungi as a result of its specific mechanism of squalene epoxidase inhibition. Treated fungi accumulate squalene while becoming deficient in ergosterol, an essential component of fungal cell membranes. The cidal action is closely associated with the development of high intracellular squalene concentrations, which are believed to interfere with fungal membrane function and cell wall synthesis. In the case of Candida albicans… 
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