Teratologic evaluation of styrene given to rats and rabbits by inhalation or by gavage.

@article{Murray1978TeratologicEO,
  title={Teratologic evaluation of styrene given to rats and rabbits by inhalation or by gavage.},
  author={Francis J. Murray and Joseph John and M. F. Balmer and Bernard A Schwetz},
  journal={Toxicology},
  year={1978},
  volume={11 4},
  pages={335-43}
}
Pregnant Sprague-Dawley rats and New Zealand white rabbits inhaled 0, 300 or 600 ppm of styrene 7 h/day from days 6 through 15 (rats) and 6 through 18 (rabbits) of gestation. Additional groups of rats were given styrene by gavage at dose levels of 0, 90 or 150 mg/kg twice daily (0, 180 or 300 mg/kg, respectively) from days 6 through 15 of gestation. Embryotoxicity and fetotoxicity were not evident in rats or rabbits inhaling styrene or in rats given the compound orally. Maternal effects… CONTINUE READING

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