Teratogenicity of phenylhydantoins in an in vitro system: molecular orbital-generated quantitative structure-toxicity relationships.

@article{Brown1989TeratogenicityOP,
  title={Teratogenicity of phenylhydantoins in an in vitro system: molecular orbital-generated quantitative structure-toxicity relationships.},
  author={Luther P. Brown and David F. V. Lewis and Oliver P. Flint and Terry C. Orton and Gordon G. Gibson},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1989},
  volume={19 12},
  pages={1471-81}
}
1. The ability of 20 mono- and di-phenylhydantoin derivatives to inhibit differentiation of rat embryo mid-brain and limb bud cells in culture has been used as an index of the teratogenic hazard represented by these compounds. 2. Molecular orbital calculations on these compounds, using the MINDO-3 (modified intermediate neglect of differential overlap) and… CONTINUE READING