Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-alpha.

@article{Bryant2001TeratogenicityO2,
  title={Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-alpha.},
  author={P. LaMont Bryant and Judith E. Schmid and Suzanne E. Fenton and Angela R. Buckalew and Barbara Abbott},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2001},
  volume={62 1},
  pages={103-14}
}
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure produces hydronephrosis and cleft palate in mice. These responses are correlated with disruption of expression of epidermal growth factor (EGF) receptor ligands, primarily EGF and transforming growth factor-alpha (TGF-alpha), and altered epithelial cell proliferation and differentiation. This research examined the role of these growth factors in TCDD-induced teratogenicity by using wild type (WT) and knockout (-/-) mice that do not express EGF… CONTINUE READING

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