Teratogenic medications and concurrent contraceptive use in women of childbearing ability with epilepsy

@article{Bhakta2015TeratogenicMA,
  title={Teratogenic medications and concurrent contraceptive use in women of childbearing ability with epilepsy},
  author={Janki Bhakta and J. Bainbridge and L. Borgelt},
  journal={Epilepsy \& Behavior},
  year={2015},
  volume={52},
  pages={212-217}
}
BACKGROUND Many antiepileptic drugs (AEDs) have the potential to cause teratogenicity. We evaluated eight antiepileptic drugs (AEDs) classified as Federal Drug Administration (FDA) pregnancy category D, X, or N designations and having documented teratogenic effects. These include carbamazepine, ethosuximide, fosphenytoin, phenobarbital, phenytoin, primidone, topiramate, and valproate. Women with epilepsy (WWE) may need one or more of these AEDs for seizure control but may be unaware of the… Expand
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References

SHOWING 1-10 OF 60 REFERENCES
Antiepileptic drug exposure and major congenital malformations: The role of pregnancy registries
TLDR
A critical discussion and comparison of important methodological aspects of AED and pregnancy registries along with a summary of results published so far is provided. Expand
Antiepileptic drugs and pregnancy outcomes
TLDR
The purpose of this document is to review the most commonly used compounds in the treatment of WWE, and to provide information on the latest experimental and human epidemiological studies of the effects of AEDs in the exposed embryos. Expand
Antiepileptic drugs: Are women aware of interactions with oral contraceptives and potential teratogenicity?
Women with epilepsy (WWE)'s knowledge of the interaction between antiepileptic drugs (AEDs) and oral contraceptives (OCs) and the potential teratogenicity of AEDs has received limited study. WeExpand
Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives
  • D. S. Reddy
  • Medicine
  • Expert review of clinical pharmacology
  • 2010
TLDR
The pharmacokinetic interactions between antiepileptic drugs (AEDs) and hormonal contraceptives and the rational strategies that may overcome these risks are described. Expand
Interactions Between Antiepileptic Drugs and Hormonal Contraception
TLDR
There are no interactions between the combined oral contraceptive pill, progesterone-only pill, medroxyprogesterone injections or levonorgestrel implants or AEDs valproic acid (sodium valproate), vigabatrin, lamotrigine, gabapentin, tiagabine, levetiracetam, zonisamide, ethosuximide and the benzodiazepines. Expand
The teratogenic effect of carbamazepine: a meta-analysis of 1255 exposures.
TLDR
In prospective studies involving 1255 cases of exposure to Carbamazepine, it was found that CBZ therapy increased the rate of congenital anomalies, mainly neural tube defects, cardiovascular and urinary tract anomalies, and cleft palate. Expand
Teratogenic effects of antiepileptic drugs
TLDR
While evidence is still accruing, recent investigations suggest that exposure to select AEDs results in altered cognitive function later in development, and there is no evidence to suggest that additional folic acid supplementation ameliorates the increased risk of congenital malformations conferred by in utero AED exposure. Expand
Antiepileptic drugs: coprescription of proconvulsant drugs and oral contraceptives: a national study of antiepileptic drug prescribing practice
TLDR
Prescribers should be alert to the possibility of pharmacodynamic and pharmacokinetic interactions between AEDs and other medication with the aging of the population of people with seizures and the polypharmacy often associated with old age, the likelihood of adversely interacting drug combinations will increase. Expand
Co-prescription of antiepileptic drugs and contraceptives.
TLDR
Fertile-age women who received AEDs often relied on less effective contraceptive methods, and prescribers should be more aware of the interaction between Aeds and OCs. Expand
Teratogenic effects of antiepileptic medications.
TLDR
Valproate should not be a first-line AED for women who are considering pregnancy, and this drug is best avoided if other effective but safer AEDs can be found for each individual woman's seizure disorder. Expand
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