Teratogenic medications and concurrent contraceptive use in women of childbearing ability with epilepsy

@article{Bhakta2015TeratogenicMA,
  title={Teratogenic medications and concurrent contraceptive use in women of childbearing ability with epilepsy},
  author={Janki Bhakta and Jacquelyn L. Bainbridge and Laura M Borgelt},
  journal={Epilepsy \& Behavior},
  year={2015},
  volume={52},
  pages={212-217}
}

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References

SHOWING 1-10 OF 60 REFERENCES
Antiepileptic drugs and pregnancy outcomes
TLDR
The purpose of this document is to review the most commonly used compounds in the treatment of WWE, and to provide information on the latest experimental and human epidemiological studies of the effects of AEDs in the exposed embryos.
Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives
  • D. Reddy
  • Medicine, Biology
    Expert review of clinical pharmacology
  • 2010
TLDR
The pharmacokinetic interactions between antiepileptic drugs (AEDs) and hormonal contraceptives and the rational strategies that may overcome these risks are described.
Teratogenic effects of antiepileptic drugs
TLDR
While evidence is still accruing, recent investigations suggest that exposure to select AEDs results in altered cognitive function later in development, and there is no evidence to suggest that additional folic acid supplementation ameliorates the increased risk of congenital malformations conferred by in utero AED exposure.
Antiepileptic drugs: coprescription of proconvulsant drugs and oral contraceptives: a national study of antiepileptic drug prescribing practice
TLDR
Prescribers should be alert to the possibility of pharmacodynamic and pharmacokinetic interactions between AEDs and other medication with the aging of the population of people with seizures and the polypharmacy often associated with old age, the likelihood of adversely interacting drug combinations will increase.
Co-prescription of antiepileptic drugs and contraceptives.
Teratogenic effects of antiepileptic medications.
Observational series on women using the contraceptive Mirena® concurrently with anti-epileptic and other enzyme-inducing drugs
TLDR
The preliminary results suggest that any increased pregnancy risk from the contraceptive efficacy of the hormone-releasing intrauterine system Mirena®, when used concurrently with enzyme-inducers falls within acceptable bounds.
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