Teratogenic effects of nitrofen on cellular and functional maturation of the rat lung.

@article{Lau1988TeratogenicEO,
  title={Teratogenic effects of nitrofen on cellular and functional maturation of the rat lung.},
  author={Clara Corona de Lau and Annie M. Cameron and O Irsula and L L Antolick and C. H. b. Langston and Robert John Kavlock},
  journal={Toxicology and applied pharmacology},
  year={1988},
  volume={95 3},
  pages={
          412-22
        }
}
The herbicide nitrofen was administered to pregnant Sprague-Dawley and Fischer-344 rats on Days 10-13 of gestation (po, 20 or 40 mg/kg daily) and the effects of maturation of the perinatal lung were evaluated. Nitrofen interfered with the ontogenetic acquisition of lung cells as DNA, RNA, and protein content were subnormal. The hypoplastic lungs in the newborns were associated with structural deficits, resulting in a profound reduction of surface area available for gas exchange and depressed… CONTINUE READING
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