Teratogenic effects in a case of maternal treatment for acute myelocytic leukaemia—neonatal and infantile course

@article{Artlich1994TeratogenicEI,
  title={Teratogenic effects in a case of maternal treatment for acute myelocytic leukaemia—neonatal and infantile course},
  author={Andreas Artlich and J{\"o}rg M{\"o}ller and Klaus Kruse and Ludwig Gortner and Alexander Tschakaloff and Eberhard Schwinger},
  journal={European Journal of Pediatrics},
  year={1994},
  volume={153},
  pages={488-491}
}
Experience with the use of cytotoxic drugs in the first trimester of pregnancy is limited. We report on the clinical phenotype and infantile development of a girl born to a 36-year-old mother. Before recognition of pregnancy, the latter had been treated for acute myelocytic leukaemia receiving cytarabine, daunorubicin and doxorubicin at conception and cytarabine and thioguanine at about 35–37 days post conception. At delivery, there were severe brachycephaly, hypoplasia of the anterior cranial… CONTINUE READING