Teratogenic effect of retinoic acid in swiss mice.

  title={Teratogenic effect of retinoic acid in swiss mice.},
  author={Paulo Roberto Veiga Quemelo and Charles M Lourenço and Luiz C{\'e}sar Peres},
  journal={Acta cirurgica brasileira},
  volume={22 6},
PURPOSE To identify the types of malformations resulting from the administration of retinoic acid (RA) to Swiss mice on different days of pregnancy. METHODS Twenty-four pregnant Swiss mice were divided into 4 groups of 6 animals each. The experimental groups received a single intraperitoneal injection of RA (70 mg/kg) on gestational days 7, 8 and 9 (D7, D8 and D9), while control animals (C) received only saline solution. RESULTS Were obtained: exencephaly (C:0; D7:16.1%; D8:25.4%; D9:0… CONTINUE READING