• Corpus ID: 22976062

Teratogenic and fetotoxic effects of two piperidine alkaloid-containing lupines (L. formosus and L. arbustus) in cows.

@article{Panter1998TeratogenicAF,
  title={Teratogenic and fetotoxic effects of two piperidine alkaloid-containing lupines (L. formosus and L. arbustus) in cows.},
  author={Kip E. Panter and Dale R Gardner and Russell J. Molyneux},
  journal={Journal of natural toxins},
  year={1998},
  volume={7 2},
  pages={
          131-40
        }
}
Cleft palate and minor front limb contractures were induced in calves by maternal ingestion of the piperidine alkaloid-containing lupines, Lupinus formosus and L. arbustus. Crooked calf disease, which includes an occasional cleft palate, is a congenital condition of widespread occurrence in cattle in the western U.S. and Canada. It is known to occur after maternal ingestion of certain species of Lupinus during specific gestational periods. Although many lupine species contain quinolizidine… 
The effect of body condition on serum concentrations of two teratogenic alkaloids (anagyrine and ammodendrine) from lupines (Lupinus species) that cause crooked calf disease.
TLDR
It is suggested that body condition may impact the risk of toxicity, teratogenicity, or both of these alkaloids in cattle as Lupinus leucophyllus or Lupinus sulphureus, respectively.
Piperidine alkaloids: human and food animal teratogens.
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These alkaloids appear to be in a metabolically active state with the teratogenic alkaloid anagyrine accumulating to its highest level in the developing seed, thus, the phenological stage posing the greatest danger to grazing livestock.
Maternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant Rats
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For the first time, this study showed that RTS can permeate the placenta barrier and entering fetal circulation, whereas the intrauterine pyrrolic metabolite was generated mainly by fetal liver but not transported from the maternal circulation.
Alkaloids as anti-quality factors in plants on western U.S. rangelands
Alkaloids constitute the largest class of plant secondary compounds, occurring in 20 to 30% of perennial herbaceous species in North America. Alkaloid-containing plants are of interest, first because
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It is shown that losses may be reduced by maintaining optimal forage conditions, adjusting grazing pressure and timing of grazing, aversive conditioning, strategic supplementation, changing livestock species, and herbicidal control.
Comparison of plasma disposition of alkaloids after lupine challenge in cattle that had given birth to calves with lupine-induced arthrogryposis or clinically normal calves.
TLDR
The findings do not support the hypothesis that between-cow differences in plasma disposition of anagyrine account for within-herd differences in risk for lupine-induced arthrogryposis.
The alkaloid profiles of Lupinus sulphureus.
TLDR
In conclusion, taxonomic classification is not sufficient to determine risk, as chemical characterization of the alkaloids must also be performed.
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