Teratogenesis and inhibition of DNA synthesis induced in rat embryos by cytosine arabinoside.

@article{Ritter1971TeratogenesisAI,
  title={Teratogenesis and inhibition of DNA synthesis induced in rat embryos by cytosine arabinoside.},
  author={E. J. Ritter and William J. Scott and J. Gerald Wilson},
  journal={Teratology},
  year={1971},
  volume={4 1},
  pages={
          7-13
        }
}
Pregnant Wistar rats were injected at day 12 of gestation with 25, 50, 100, or 200 mg/kg cytosine arabinoside. One to 27 hours later 3H-thymidine was also injected followed 2 hours later by surgical removal of one uterine horn. The remaining horn was left in situ until day 20 for evaluation of embryotoxicity (malformation, death, or growth retardation). Half of the embryos in the removed horn were prepared individually for whole-embryo scintillation counts and the other half were homogenized… 
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Cellular and biochemical aspects of growth retardation in rat fetuses induced by maternal administration of selected anticancer agents.
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Limb development in mouse embryos. II. Reduction defects, cytotoxicity and inhibition of DNA synthesis produced by cytosine arabinoside.
TLDR
Various morphological and biochemical parameters were used to study the mode of interference by cytosine arabinoside (Ara-C) in critical phases of embryonic limb development, finding that there may be a common cellular basis underlying these two types of digital defects.
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TLDR
The developmental no-observed-adverse-effect-level (NOAEL) of Ara-C in the pregnant mouse is lower than 0.5 mg/kg/day, while the NOAEL for maternal toxicity is 0.1-beta-D-Arabinofuranosylcytosine (Ara-C).
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