Teratogen-induced eye defects mediated by p53-dependent apoptosis

  title={Teratogen-induced eye defects mediated by p53-dependent apoptosis},
  author={Judith A. Wubah and Monier M. Ibrahim and Xiang Gao and Diep D. Nguyen and M. Michele Pisano and Thomas B Knudsen},
  journal={Current Biology},
BACKGROUND Many birth defects are believed to involve gene-environment interactions, although the mechanisms involved are poorly understood. Apoptosis is a common effect of many kinds of environmental stresses on the developing embryo; therefore, mechanisms of teratogenesis may be approached within the context of the cell death program. The p53 tumor… CONTINUE READING