Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting ‐ a review

  title={Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting ‐ a review},
  author={J. Axel Zeitler and Philip F. Taday and David A. Newnham and Michael Pepper and Keith C. Gordon and Thomas Rades},
  journal={Journal of Pharmacy and Pharmacology},
Terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) are two novel techniques for the physical characterization of pharmaceutical drug materials and final solid dosage forms, utilizing spectral information in the far infrared region of the electromagnetic spectrum. This review focuses on the development and performance of pharmaceutical applications of terahertz technology compared with other tools for physical characterization. TPS can be used to characterize crystalline… 
Terahertz pulsed spectroscopy and imaging for pharmaceutical applications: a review.
  • Yaochun Shen
  • Physics
    International journal of pharmaceutics
  • 2011
Development and Application of Terahertz Pulsed Imaging for Nondestructive Inspection of Pharmaceutical Tablet
  • Yaochun Shen, P. Taday
  • Materials Science, Physics
    IEEE Journal of Selected Topics in Quantum Electronics
  • 2008
Terahertz pulsed imaging (TPI) was evaluated for nondestructively characterizing the 3-D internal structures of pharmaceutical tablets. The structural information of a pharmaceutical tablet, such as
Inspection of Solid Dosage Forms using THz Imaging Spectroscopy
Abstract The present work describes a laboratory terahertz (THz) imaging spectroscopy system and its possibilities to inspect solid dosage forms in the form of coated tablets and capsules. Moreover,
Terahertz pulsed imaging, a novel process analytical tool to investigate the coating characteristics of push-pull osmotic systems.
Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating.
  • L. Ho, R. Müller, J. A. Zeitler
  • Materials Science
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2009
Terahertz Spectroscopy: Encoding the Discovery, Instrumentation, and Applications toward Pharmaceutical Prospectives
The review critically outlines here all the pharmaceutical applications of THz spectroscopy including protein analyses, crystallinity studies, evaluating tablet films and coats, medicinal aging variations, and detection of illicit drugs, along with the advantages over traditional techniques.
Biosensing with T-ray spectroscopy
In the recent years, it has been shown that terahertz (or T-ray) spectroscopy is a versatile tool for biosensing and safety applications. This is due to the fact that the THz-spectra of many


Terahertz pulsed imaging and spectroscopy for biomedical and pharmaceutical applications.
Two techniques that utilize THz radiation, terahertz pulsed imaging (TPI) and teraHertz pulsing spectroscopy (TPS) are described, both of which have a variety of possible applications in biomedical imaging and pharmaceutical science.
Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity.
In this study, four drugs with different solid-state properties were analyzed using TPS and levels of polymorphism and crystallinity were quantified, demonstrating that TPS is an analytical technique of potential in quantifying solid- state properties of pharmaceutical compounds.
Nondestructive analysis of tablet coating thicknesses using terahertz pulsed imaging.
In the study reported herein, it was possible to distinguish between two brands of across-the-counter ibuprofen tablets and terahertz pulsed imaging offers a potential technique to examine coatings quickly and nondestructively.
Applications of terahertz spectroscopy to pharmaceutical sciences
  • P. Taday
  • Chemistry
    Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences
  • 2003
Terahertz pulse spectroscopy is a high–throughput technique with many areas of potential exploitation in the pharmaceutical industry; these issues are discussed in this paper.
3D chemical mapping using terahertz pulsed imaging
We report the use of a terahertz pulsed imaging technique for three-dimensional chemical mapping. Terahertz radiation reflected from a sample was measured pixel-by-pixel in time domain using a
Applications of attenuated total reflection infrared spectroscopic imaging to pharmaceutical formulations.
It has been found that the diamond ATR imaging accessory gives information on the overall distribution of different components in a tablet while the micro-ATR imaging technique provides a closer look at the tablet with 4-microm spatial resolution.
Infrared imaging of laser-induced heating during Raman spectroscopy of pharmaceutical solids.
Detection and identification of explosives using terahertz pulsed spectroscopic imaging
The absorption spectrum of the explosive 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) has been measured using a conventional Fourier transform infrared spectroscopy and by terahertz pulsed
Using Terahertz pulse spectroscopy to study the crystalline structure of a drug: a case study of the polymorphs of ranitidine hydrochloride.
It is concluded that the Terahertz pulse spectroscopy method has a wide range of applications in pharmaceutical science including formulation, high throughput screening, and inspection in storage.