Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch.

  title={Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch.},
  author={Huanjun Lu and Thien-Luan Nguyen and Gyu-Sang Hong and Sungmin Pak and Hyesu Kim and Hyungsup Kim and Dong-Yoon Kim and Sung-Yon Kim and Yiming Shen and Pan Dong Ryu and Mi-Ock Lee and Uhtaek Oh},
  journal={The Journal of clinical investigation},
The baroreceptor reflex is a powerful neural feedback that regulates arterial pressure (AP). Mechanosensitive channels transduce pulsatile AP to electrical signals in baroreceptors. Here we show that tentonin 3 (TTN3/TMEM150C), a cation channel activated by mechanical strokes, is essential for detecting AP changes in the aortic arch. TTN3 was expressed in nerve terminals in the aortic arch and nodose ganglion (NG) neurons. Genetic ablation of Ttn3 induced ambient hypertension, tachycardia, AP… 

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