Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch.

  title={Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch.},
  author={Huanjun Lu and Thien-Luan Nguyen and Gyu-Sang Hong and S. Pak and Hyesu Kim and Hyungsup Kim and Dong-Yoon Kim and Sung-Yon Kim and Yi-ming Shen and P. Ryu and Mi-Ock Lee and U. Oh},
  journal={The Journal of clinical investigation},
The baroreceptor reflex is a powerful neural feedback that regulates arterial pressure (AP). Mechanosensitive channels transduce pulsatile AP to electrical signals in baroreceptors. Here we show that tentonin 3 (TTN3/TMEM150C), a cation channel activated by mechanical strokes, is essential for detecting AP changes in the aortic arch. TTN3 was expressed in nerve terminals in the aortic arch and nodose ganglion (NG) neurons. Genetic ablation of Ttn3 induced ambient hypertension, tachycardia, AP… Expand
3 Citations
Tentonin 3 as a baroreceptor mechanosensor: not a stretch.
This study expands the molecular profiles of baroreceptors and provides new insights into molecular mechanisms underlying the regulation of cardiovascular functions through baroreceptor function. Expand
Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.
It is found that Piezo2 was dominantly expressed in baroreceptor nodose ganglia neurons and aortic nerve endings in Wistar-Kyoto (WKY) rats and downregulated in SHR and hypertensive model rats, demonstrating thatPiezo2 not Piezo1 may act as baroreceptors to regulate arterial BP in rats. Expand
Patch-seq of mouse DRG neurons reveals candidate genes for specific mechanosensory functions
Correlation of current signatures with single-cell transcriptomes provides a one-to-one correspondence between mechanoelectric properties and transcriptomically-defined neuronal populations, and gene expression differential comparison provides a set of candidate genes for mechanotransduction complexes. Expand


TRPC5 channels participate in pressure-sensing in aortic baroreceptors
The results suggest that TRPC5 channels represent a key pressure transducer in the baroreceptors and play an important role in maintaining blood pressure stability. Expand
A Molecular Component of the Arterial Baroreceptor Mechanotransducer
The finding of the gamma subunit of ENaC localized to the site of mechanotransduction in baroreceptor nerve terminals innervating the aortic arch and carotid sinus suggests that ENac subunits may be components of the barorecept mechanotranducer and pave the way to a better definition of mechanisms responsible for blood pressure regulation and hypertension. Expand
The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation
Testing the hypothesis that a member of the acid-sensing ion channel (ASIC) subfamily of the DEG/ENaC superfamily is an important determinant of the arterial baroreceptor reflex found that aortic baroreceptors in the nodose ganglia and their terminals express ASIC2. Expand
Sensing of Blood Pressure Increase by Transient Receptor Potential Vanilloid 1 Receptors on Baroreceptors
These findings provide important new information that TRPV1 is expressed along the entire baroreceptive afferent pathway and can function as mechanoreceptors to detect the increase in blood pressure and maintain the homoeostasis. Expand
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
Genetic ablation of both Piezo1 and Piezo2 in the nodose and petrosal sensory ganglia of mice abolished drug-induced baroreflex and aortic depressor nerve activity, suggesting that PIEZO1 and PIEzO2 are the long-sought baroreceptor mechanosensors critical for acute blood pressure control. Expand
Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws
Genetic mapping reveals that PIEZO2 neurons form a distinctive mechanosensory structure: macroscopic claws that surround the aortic arch and exude fine end-net endings that form flower-spray terminals that are dispensable for baroreception. Expand
Baroreceptors, baroreceptor unloading, and the long-term control of blood pressure.
  • T. Thrasher
  • Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2005
This review focuses on effects of baroreceptor denervation in the regulation of MAP in human subjects compared with animal studies; the relationship between vascular compliance, MAP, and baroreceptors resetting; and the effect of chronicbaroreceptor unloading on theregulation of MAP. Expand
Baroreceptor Dynamics and Their Relationship to Afferent Fiber Type and Hypertension
The dynamic response curves of SHR and NTR aortas were determined and found to be flat to much higher frequencies than those of the baroreceptors, thus aortic wall dynamics do not limit the frequency range of theBaroreceptor. Expand
Mechanisms of blood pressure variability-induced cardiac hypertrophy and dysfunction in mice with impaired baroreflex.
More frequent blood pressure rises in subjects with high blood pressure variability activate mechanosensitive and autocrine pathways leading to cardiac hypertrophy and dysfunction even in the absence of hypertension. Expand
Evidence for Mechanosensitive Channel Activity of Tentonin 3/TMEM150C
Evidence is presented to support that TTN3 is a pore-forming unit, not an amplifying adaptor for Piezo1 activity, and evidence based on co-expression of TTN 3 and Peizo1 and mutant variants of the pore region of TTn3 is supported. Expand