Tentative model for the mapping of D epitopes on the RhD polypeptide.

  title={Tentative model for the mapping of D epitopes on the RhD polypeptide.},
  author={J. P. Cartron and C Rouillac and Caroline le van Kim and Isabelle Mouro and Yves Colin},
  journal={Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine},
  volume={3 6},
The partial D phenotypes correspond to D-positive individuals that may develop anti-D antibodies following immunization by transfusion or pregnancy, since they lack some of the D epitopes that compose the D antigen. When these red cells are tested with a panel of human monoclonal anti-D, different patterns of reactivity are observed and at least nine distinct epitopes termed epD1 to epD9 can be identified. Molecular analysis of partial D variants have shown that the loss of some D epitopes is… CONTINUE READING

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