Tension on chromosomes increases the number of kinetochore microtubules but only within limits.

@article{King2000TensionOC,
  title={Tension on chromosomes increases the number of kinetochore microtubules but only within limits.},
  author={Jennifer M. King and R. Bruce Nicklas},
  journal={Journal of cell science},
  year={2000},
  volume={113 Pt 21},
  pages={3815-23}
}
When chromosomes attach properly to a mitotic spindle, their kinetochores generate force in opposite directions, creating tension. Tension is presumed to increase kinetochore microtubule number, but there has been no direct evidence this is true. We micromanipulated grasshopper spermatocyte chromosomes to test this assumption and found that tension does indeed affect the number of kinetochore microtubules. Releasing tension at kinetochores causes a drop to less than half the original number of… CONTINUE READING

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