Tension directly stabilizes reconstituted kinetochore-microtubule attachments

@article{Akiyoshi2010TensionDS,
  title={Tension directly stabilizes reconstituted kinetochore-microtubule attachments},
  author={Bungo Akiyoshi and Krishna K. Sarangapani and Andrew F. Powers and Christian Richard Nelson and Steve L. Reichow and Hugo Arellano-Santoyo and Tamir Gonen and Jeffrey A Ranish and Charles L Asbury and Sue Biggins},
  journal={Nature},
  year={2010},
  volume={468},
  pages={576-579}
}
Kinetochores are macromolecular machines that couple chromosomes to dynamic microtubule tips during cell division, thereby generating force to segregate the chromosomes. Accurate segregation depends on selective stabilization of correct ‘bi-oriented’ kinetochore–microtubule attachments, which come under tension as the result of opposing forces exerted by microtubules. Tension is thought to stabilize these bi-oriented attachments indirectly, by suppressing the destabilizing activity of a kinase… CONTINUE READING
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