• Corpus ID: 250243770

Tension-clock control of human mitotic chromosome oscillations

@inproceedings{Burroughs2022TensionclockCO,
  title={Tension-clock control of human mitotic chromosome oscillations},
  author={Nigel J. Burroughs and Andrew D. McAinsh},
  year={2022}
}
paired (sister) chromosomes are observed to perform approximate saw-tooth oscillations across the cell mid-plane. Experimental data suggests that these oscillations are regulated through intersister tension. We propose a time dependent tension threshold model that exhibits three stable periodic solutions and the phase can be generated semi-analytically. Incorporation of diffusive noise reproduces realistic oscillations, with realistic pe-riods, amplitudes and reproducing the observa-tion that… 

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