Tension Sensing by Aurora B Kinase is Independent of Survivin-Based Centromere Localization

@inproceedings{Campbell2013TensionSB,
  title={Tension Sensing by Aurora B Kinase is Independent of Survivin-Based Centromere Localization},
  author={Christopher S Campbell and Arshad Desai},
  booktitle={Nature},
  year={2013}
}
Accurate segregation of the replicated genome requires chromosome biorientation on the spindle. Biorientation is ensured by Aurora B kinase (Ipl1), a member of the four-subunit chromosomal passenger complex (CPC). Localization of the CPC to the inner centromere is central to the current model for how tension ensures chromosome biorientation: kinetochore–spindle attachments that are not under tension remain close to the inner centromere and are destabilized by Aurora B phosphorylation, whereas… CONTINUE READING
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