Tensin: a potential link between the cytoskeleton and signal transduction.


Cytoskeletal proteins provide the structural foundation that allows cells to exist in a highly organized manner. Recent evidence suggests that certain cytoskeletal proteins not only maintain structural integrity, but might also be associated with signal transduction and suppression of tumorigenesis. Since the time of the discovery of tensin, a fair amount of data has been gathered which supports the notion that tensin is one such protein possessing these characteristics. In this review, we discuss recent studies that: (1) elucidate a role for tensin in maintenance of cellular structure and signal transduction; (2) implicate tensin as the anchor for actin filaments at the focal adhesion; (3) describe the phosphorylation of tensin; (4) describe potential targets for its Src homology region 2 domain; (5) describe the association between tensin and the nuclear protein p130; and (6) demonstrate that increased tensin expression in a cell line appears to reduce its transformation potential.


Citations per Year

517 Citations

Semantic Scholar estimates that this publication has 517 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Lo1994TensinAP, title={Tensin: a potential link between the cytoskeleton and signal transduction.}, author={Siu Hung Keith Lo and Ellen L. Weisberg and Liang Chen}, journal={BioEssays : news and reviews in molecular, cellular and developmental biology}, year={1994}, volume={16 11}, pages={817-23} }