Tensile mechanical properties of collagen type I and its enzymatic crosslinks.

@article{Kwansa2016TensileMP,
  title={Tensile mechanical properties of collagen type I and its enzymatic crosslinks.},
  author={Albert L Kwansa and Raffaella De Vita and Joseph Freeman},
  journal={Biophysical chemistry},
  year={2016},
  volume={214-215},
  pages={1-10}
}
Collagen type I crosslink type and prevalence can be influenced by age, tissue type, and health; however, the role that crosslink chemical structure plays in mechanical behavior is not clear. Molecular dynamics simulations of ~65-nm-long microfibril units were used to predict how difunctional (deH-HLNL and HLKNL) and trifunctional (HHL and PYD) crosslinks respond to mechanical deformation. Low- and high-strain stress-strain regions were observed, corresponding to crosslink alignment. The high… CONTINUE READING