Tensile forces govern germ-layer organization in zebrafish

  title={Tensile forces govern germ-layer organization in zebrafish},
  author={Michael Krieg and Yohanna Arboleda-Estudillo and P.-H. Puech and Jos K{\"a}fer and François Graner and Daniel J M{\"u}ller and C.-P. Heisenberg},
  journal={Nature Cell Biology},
Understanding the factors that direct tissue organization during development is one of the most fundamental goals in developmental biology. Various hypotheses explain cell sorting and tissue organization on the basis of the adhesive and mechanical properties of the constituent cells. However, validating these hypotheses has been difficult due to the lack of appropriate tools to measure these parameters. Here we use atomic force microscopy (AFM) to quantify the adhesive and mechanical properties… CONTINUE READING
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