Tensegrity: the architectural basis of cellular mechanotransduction.

  title={Tensegrity: the architectural basis of cellular mechanotransduction.},
  author={Donald E. Ingber},
  journal={Annual review of physiology},
  • D. Ingber
  • Published 1997
  • Biology
  • Annual review of physiology
Physical forces of gravity, hemodynamic stresses, and movement play a critical role in tissue development. Yet, little is known about how cells convert these mechanical signals into a chemical response. This review attempts to place the potential molecular mediators of mechanotransduction (e.g. stretch-sensitive ion channels, signaling molecules, cytoskeleton, integrins) within the context of the structural complexity of living cells. The model presented relies on recent experimental findings… 

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