Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load

@inproceedings{Dex2017TenomodulinIR,
  title={Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load},
  author={Sarah Dex and Paolo Alberton and Lena Willkomm and Thomas S{\"o}llradl and Sandra Bago and Stefan Milz and Mehdi Shakibaei and Anita Ignatius and Wilhelm Bloch and Hauke Clausen-Schaumann and Chisa Shukunami and Matthias Schieker and Denitsa Docheva},
  booktitle={EBioMedicine},
  year={2017}
}
Tendons are dense connective tissues that attach muscles to bone with an indispensable role in locomotion because of their intrinsic properties of storing and releasing muscle- generated elastic energy. Tenomodulin (Tnmd) is a well-accepted gene marker for the mature tendon/ligament lineage and its loss-of -function in mice leads to a phenotype with distinct signs of premature aging on tissue and stem/progenitor cell levels. Based on these findings, we hypothesized that Tnmd might be an… CONTINUE READING
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