Tenofovir treatment duration predicts proteinuria in a multiethnic United States Cohort of children and adolescents with perinatal HIV-1 infection.

@article{Purswani2013TenofovirTD,
  title={Tenofovir treatment duration predicts proteinuria in a multiethnic United States Cohort of children and adolescents with perinatal HIV-1 infection.},
  author={Murli Purswani and Kunjal Patel and Jeffrey B. Kopp and George R. Seage and Miriam C. Chernoff and Rohan Hazra and George K. Siberry and Lynne Mofenson and Gwendolyn B. Scott and Russell B. van Dyke},
  journal={The Pediatric infectious disease journal},
  year={2013},
  volume={32 5},
  pages={495-500}
}
BACKGROUND Tenofovir is associated with renal proximal tubule injury. Such toxicity has not been extensively studied in HIV-1-infected children, in whom tenofovir is increasingly used. METHODS History, urine and blood were collected at regular intervals from 448 children and adolescents with perinatal HIV-1 infection followed in the Pediatric HIV/AIDS Cohort study. Relationships between tenofovir use and proteinuria and chronic kidney disease (CKD) outcomes were examined using multivariable… CONTINUE READING
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