Tenofovir-induced kidney injury.

  title={Tenofovir-induced kidney injury.},
  author={Michael D Gitman and David A Hirschwerk and Cindy H Baskin and Pravin C. Singhal},
  journal={Expert opinion on drug safety},
  volume={6 2},
Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor with activity against both HIV and the hepatitis B virus. It has had minimal nephrotoxic effects in early clinical trials, but as clinical use has widened, case reports describing tenofovir-induced renal tubular damage, Fanconi's syndrome and diabetes insipidus have been described. The authors review the pharmacokinetics, mechanism of action and clinical uses of tenofovir disoproxil fumarate. The large clinical trials… CONTINUE READING