Tenofovir disoproxil fumarate therapy for chronic hepatitis B in human immunodeficiency virus/hepatitis B virus-coinfected individuals for whom interferon-alpha and lamivudine therapy have failed.

@article{Ristig2002TenofovirDF,
  title={Tenofovir disoproxil fumarate therapy for chronic hepatitis B in human immunodeficiency virus/hepatitis B virus-coinfected individuals for whom interferon-alpha and lamivudine therapy have failed.},
  author={Maria B Ristig and Jeffrey S. Crippin and Judith Aberg and William G. Powderly and Mauricio Lisker-Melman and Lisa Kessels and Pablo Tebas},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={186 12},
  pages={1844-7}
}
A significant proportion of human immunodeficiency virus (HIV) infected patients are coinfected with hepatitis B virus (HBV). Currently available treatments for chronic hepatitis B (interferon [IFN]-alpha and lamivudine [3TC]) have limited long-term utility because of side effects or of the development of resistance. Tenofovir disoproxil fumarate (TDF) is a nucleotide analog with excellent activity in vitro against HBV, which is also active against 3TC-resistant HBV variants. In this 24-week… CONTINUE READING

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